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GβL Antibody
SPA-04911
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | GβL |
| Gene Abbr. | MLST8 |
| Gene ID | 64223 |
| Full Name | MTOR associated protein, LST8 homolog |
| Alias | GBL, GbetaL, LST8, POP3, WAT1 |
| Introduction | Cell growth is a fundamental biological process whereby cells accumulate mass and increase in size. The mammalian Target of Rapamycin (mTOR) pathway regulates growth by coordinating energy and nutrient signals with growth factor-derived signals. mTOR is a large protein kinase with two different complexes. One complex contains mTOR, GβL, and raptor, which is a target of rapamycin. The other complex, insensitive to rapamycin, includes mTOR, GβL, and rictor. GβL associates with the kinase domain of mTOR and stimulates mTOR kinase activity. A reduction in GβL expression has been shown to decrease in vivo phosphorylation of S6K1. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone No. | 86B8 |
| Immunogen | Synthetic peptide corresponding to residues surrounding Gln210 of human GβL. |
| Source/Purification | Antibody is produced by immunizing rabbits with a synthetic peptide corresponding to residues surrounding Gln210 of human GβL. |
| Usage | |
|---|---|
| Application | WB, IP |
| Dilutions | Western Blot (1:1000); Immunoprecipitation (1:50) |
| MW(KDa) | 37 |
| Reactivity | Human, Mouse, Rat, Monkey |
| Sensitivity | Endogenous |
| Specificity | It detects endogenous levels of total GβL protein. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. |
| Preservative | Less than 0.02% Sodium Azide |
| Storage Temp. | Store at -20 °C. |
| Handling | Do not aliquot the antibody. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.