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GITR/TNFRSF18 Antibody
SPA-10881
| Size | Price |
| 0.025 mg | Online Inquiry |
| 0.1 mg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | TNF receptor |
| Gene Abbr. | TNFRSF18 |
| Gene ID | 8784 |
| Full Name | TNF receptor superfamily member 18 |
| Alias | AITR, CD357, ENERGEN, GITR, GITR-D |
| Introduction | GITR or TNFRSF18 is a 241 amino acid novel member of the tumor necrosis factor receptor superfamily and a receptor for TNFSF18. It has three extracytoplasmic cysteine-rich pseudorepeats, a small cytoplasmic tail and a DEATH domain. It is an essential regulator of immune responses to self tissues and pathogens and plays a key role in dominant immunological self-tolerance maintained by CD25 (+) CD4 (+) regulatory T cells. It is known to be involved in regulation of CD3-driven T-cell activation and programmed cell death and also in interactions between activated T-lymphocytes and endothelial cells. In mammalian cells it mediates NF-kappa-B activation via TRAF2 and modulates T lymphocyte survival in peripheral tissues. It is mostly expressed in lymph node, peripheral blood leukocytes and weakly expressed in spleen. GITR and its ligand are also known to be involved in atopic dermatitis. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | Synthetic peptide directed towards the C terminal of human TNFRSF18. Peptide sequence LRSQCMWPRETQLLLEVPPSTEDARSCQFPEEERGERSAEEKGRLGDLWV. The peptide sequence for this immunogen was taken from within the described region. |
| Usage | |
|---|---|
| Application | WB, IHC |
| Dilutions | Western Blot (1:1000); Immunohistochemistry (1:10-1:500) |
| Reactivity | Human |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS and 2% Sucrose. |
| Preservative | 0.09% Sodium Azide |
| Storage Temp. | Store at -20 °C. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.