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GIPR Antibody
SPA-04459
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | GIPR |
| Gene Abbr. | GIPR |
| Gene ID | 2696 |
| Full Name | gastric inhibitory polypeptide receptor |
| Alias | PGQTL2 |
| Introduction | GIPR is a 7-transmembrane receptor for GIP (glucose-dependent insulinotropic polypeptide or gastric inhibitory polypeptide). The 466 amino acid (aa) human GIPR contains 176 extracellular domain (ECD) aa that share 77% and 81% aa identity with mouse and rat GIPR ECD, respectively. A splice isoform of 430 aa has a deletion of aa 58-93 in the N-terminal ECD, while isoforms of 491 and 419 aa have alternate C-terminal cytoplasmic sequences. Engagement by GIP on pancreatic b‑cells activates adenylate cyclase to regulate insulin compensation in the presence of high circulating glucose. GIPR is also expressed on adipocytes, osteoblasts and myelinating Schwann cell membranes. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 591853 |
| Isotype | IgG1 |
| Immunogen | NS0 mouse myeloma cell line transfected with human GIPR. Met1-Cys466. Accession # P48546. |
| Usage | |
|---|---|
| Application | FC, IHC |
| Dilutions | Flow Cytometry (0.25 µg/10^6 cells); Immunohistochemistry (8-25 µg/mL) |
| Reactivity | Human |
| Specificity | Detects human GIPR in direct ELISAs. Stains human GIPR transfected cells but not irrelevant transfectants. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.