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Gefitinib (ZD1839)
SPC-00936
CAS No. 184475-35-2
| Size | Price |
| 10 mM (1 mL in DMSO) | Online Inquiry |
| 100 mg | Online Inquiry |
| 250 mg | Online Inquiry |
| Bulk Size | Online Inquiry |
EGFR inhibitor ; Autophagy activator ; Apoptosis related activator
| Description |
|---|
| Gefitinib (ZD-1839, Iressa) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively. Gefitinib promotes autophagy and apoptosis of lung cancer cells via blockade of the PI3K/AKT/mTOR pathway. |
| Product Details | |
|---|---|
| CAS No. | CAS No. 184475-35-2 |
| Description | Gefitinib (ZD-1839, Iressa) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively. Gefitinib promotes autophagy and apoptosis of lung cancer cells via blockade of the PI3K/AKT/mTOR pathway. |
| Formula | C22H24ClFN4O3 |
| Molecular Weight | 446.90 |
| Storage | 3 years -20°C powder 2 years -80°C in solvent |
| Synonyms | Iressa |
| SMILES | COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4 |
| Solubility | DMSO |
| Usage | |
|---|---|
| Storage | 3 years -20°C powder 2 years -80°C in solvent |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.