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GCH1 Antibody
SPA-04356
| Size | Price |
| 0.1 mL | Online Inquiry |
| 25 µL | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | GCH1 |
| Gene Abbr. | GCH1 |
| Gene ID | 2643 |
| Full Name | GTP cyclohydrolase 1 |
| Alias | DYT14, DYT5, DYT5a, GCH, GTP-CH-1 |
| Introduction | This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme. [provided by RefSeq] |
| Product Details | |
|---|---|
| Host | Goat |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | Peptide with sequence C-GKVHIGYLPNKQ corresponding to internal region according to NP_001019195.1, NP_001019241.1, NP_001019242.1. |
| Usage | |
|---|---|
| Application | WB, ELISA |
| Dilutions | Western Blot (0.5-1.5 µg/mL); ELISA (1:16000) |
| Reactivity | Human, Mouse, Rat |
| Specificity | This antibody is expected to recognize all four isoforms (NP_000152.1 ; NP_001019195.1 ; NP_001019241.1 ; NP_001019242.1). |
| Storage & Handling | |
|---|---|
| Storage Buffer | Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA. |
| Preservative | 0.02% Sodium Azide |
| Storage Temp. | Store at -20 °C. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.