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FPR1 Antibody
SPA-04121
| Size | Price |
| 0.025 mg | Online Inquiry |
| 0.1 mg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | FPR1 |
| Gene Abbr. | FPR1 |
| Gene ID | 2357 |
| Full Name | formyl peptide receptor 1 |
| Alias | FMLP, FPR |
| Introduction | FPR1 is a member of chemoattractant/chemokine GPCRs expressed mainly on leukocytes, neutrophils and monocytes. FPR1 is a seven transmembrane pertussis toxin-sensitive GPCR and binds to formylated peptides generated by bacteria resulting in leukocyte trafficking to the site of inflammation. Ligand binding to FPR results in activation of multiple effectors including phospholipase C leading to calcium mobilization and PKC activation. Other implications of FPR signaling include polarization of actin cytoskeleton, activation of various integrins, increased cell migration, phagocytosis, degranulation and release of reactive oxygen intermediates. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 350418 |
| Isotype | IgG2A |
| Immunogen | HEK293 human embryonic kidney cell line transfected with human FPR1. Met1-Lys350. Accession # NP_002020. |
| Usage | |
|---|---|
| Application | FC |
| Dilutions | Flow Cytometry (2.5 μg/10^6 cells) |
| Reactivity | Human |
| Specificity | Detects human FPR1. Stains human FPR1-transfected cells but not irrelevant transfectants. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.