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FOXO3 Antibody
SPA-04097
| Size | Price |
| 100 µL | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | FoxO |
| Gene Abbr. | FOXO3 |
| Gene ID | 2309 |
| Full Name | forkhead box O3 |
| Alias | AF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A |
| Introduction | Forkhead box O3 (FoxO3) is a ubiquitously expressed 72 kDa transcriptional regulator that is involved in cellular differentiation, angiogenesis, tumor progression, apoptosis, and the responses to oxidative stress and DNA damage. Phosphorylation of FoxO3 by Akt induces its association with 14-3-3 proteins and its retention in the cytoplasm. In response to the loss of survival factors, dephosphorylation of FoxO3 induces its translocation to the nucleus where it promotes apoptosis. Its level of acetylation is regulated in response to cellular metabolic requirements. Within amino acids 372‑673 (C-terminal to the DNA binding domain), human FoxO3 shares 95% aa sequence identity with mouse and rat FoxO3. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human FOXO3A. |
| Usage | |
|---|---|
| Application | WB, ChIP, IF, IHC, IP |
| Dilutions | Western Blot (1:500-1:3000); Immunofluorescence (1:100-1:1000); Immunohistochemistry (1:100-1:1000); Immunoprecipitation (1:100-1:500) |
| MW(KDa) | 78-82 |
| Reactivity | Human, Mouse, Rat, Porcine, Bovine, Sheep |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS, 20% Glycerol (pH 7). |
| Preservative | 0.025% Proclin 300 |
| Storage Temp. | Aliquot and store at -20 °C or -80 °C. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.