Online Inquiry
FGFR5/FGFRL1 Antibody
SPA-03964
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | FGF Receptor |
| Gene Abbr. | FGFRL1 |
| Gene ID | 53834 |
| Full Name | fibroblast growth factor receptor like 1 |
| Alias | FGFR-5, FGFR5, FHFR |
| Introduction | The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq] |
| Product Details | |
|---|---|
| Host | Goat |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human FGF R5/FGFRL1. Ala25-Pro378. Accession # Q8N441. |
| Usage | |
|---|---|
| Application | WB |
| Dilutions | Western Blot (0.1 µg/mL) |
| Reactivity | Human |
| Specificity | Detects human FGF R5/FGFRL1 in direct ELISAs and Western Blots. In direct ELISAs and Western Blots, approximately 65% cross‑reactivity with recombinant mouse (rm) FGF R5 and rmFGF R5 beta is observed and less than 1% cross-reactivity with recombinant human (rh) FGF R1 alpha (IIIb), rhFGF R1 alpha (IIIc), rhFGF R1 beta (IIIb), rhFGF R1 beta (IIIc), rhFGF R2 alpha (IIIb), rhFGF R2 alpha (IIIc), rhFGF R2 beta (IIIb), rhFGF R2 beta (IIIc), rhFGF R3 alpha (IIIb), rhFGF R3 (IIIc), and rhFGF R4 is observed. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.