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F4/80 Antibody
SPA-03738
| Size | Price |
| 0.025 mg | Online Inquiry |
| 0.125 mg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | F4/80 |
| Gene Abbr. | ADGRE1 |
| Gene ID | 2015 |
| Full Name | adhesion G protein-coupled receptor E1 |
| Alias | EMR1, TM7LN3 |
| Introduction | F4/80 is a 160 kD cell surface glycoprotein that is a member of the EGFTM7 family of proteins which shares 68% overall amino acid identity with human EGF module-containing mucinlike hormone receptor 1 (EMR1). Expression of F4/80 is heterogeneous and is reported to vary during macrophage maturation and activation. The F4/80 antigen is expressed on a wide range of mature tissue macrophages including Kupffer cells, Langerhans, microglia, macrophages located in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma and macrophages in the red pulp of the spleen. F4/80 expression has also been reported on a subpopulation of dendritic cells but is absent from macrophages located in T cell areas of the spleen and lymph node. The ligands and biological functions of the F4/80 antigen have not yet been determined but recent studies suggest a role for F4/80 in the generation of efferent CD8+ve regulatory T cells. |
| Product Details | |
|---|---|
| Host | Rat |
| Clonality | Monoclonal |
| Clone No. | BM8 |
| Isotype | IgG2A |
| Immunogen | BALB/c macrophages obtained from 14-day-old bone marrow cell cultures. |
| Usage | |
|---|---|
| Application | WB, FC, IF, IHC |
| Dilutions | Western Blot (1:100-1:2000); Flow Cytometry (1:10-1:1000); Immunohistochemistry (1:10-1:500) |
| Reactivity | Mouse |
| Validation | Knockout Validated. |
| Storage & Handling | |
|---|---|
| Storage Buffer | 0.2 µm filtered solution in PBS and 0.1% BSA. |
| Preservative | 0.02% Sodium Azide |
| Storage Temp. | Store at 4 °C. |
| Handling | Do not freeze. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.