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ETS-2 Antibody
SPA-03713
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | ETS-2 |
| Gene Abbr. | ETS2 |
| Gene ID | 2114 |
| Full Name | ETS proto-oncogene 2, transcription factor |
| Alias | ETS2IT1 |
| Introduction | ETS-2 is a member of the E26 Transformation-specific Sequence (ETS) transcription factor family, members of which bind to a core GGAA/T DNA sequence in the promoter region of target genes to activate gene expression. ETS-2 activates expression of a wide variety of target genes, including MMPs, TERT, TCR, uPA, and oncogenic miRNAs. It's activity has been shown to be important for cell growth and differentiation, bone formation, autoimmune disease, and cancer progression. Phosphorylation by MAP kinase at Thr72 upregulates the function of ETS-2, suggesting that therapeutic strategies targeting ETS-2 may provide an alternative to MEK inhibitor therapy. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone No. | D6L4J |
| Immunogen | Synthetic peptide corresponding to residues surrounding Glu201 of human ETS-2 protein. |
| Source/Purification | Antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu201 of human ETS-2 protein. |
| Usage | |
|---|---|
| Application | WB, IF |
| Dilutions | Western Blot (1:1000) |
| MW(KDa) | 61 |
| Reactivity | Human |
| Sensitivity | Endogenous |
| Specificity | It recognizes endogenous levels of total ETS-2 protein. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. |
| Preservative | Less than 0.02% Sodium Azide |
| Storage Temp. | Store at -20 °C. |
| Handling | Do not aliquot the antibody. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.