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ERManI Antibody
SPA-03678
| Size | Price |
| 0.025 mL | Online Inquiry |
| 0.1 mL | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | ERManI |
| Gene Abbr. | MAN1B1 |
| Gene ID | 11253 |
| Full Name | mannosidase alpha class 1B member 1 |
| Alias | ERMAN1, ERManI, MANA-ER, MRT15 |
| Introduction | ERManI, also known as endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase or MAN1B1, is a putative ER resident mannosidase that plays a rate-limiting role in generating a signal that targets misfolded N-linked glycoproteins for ER-associated degradation (ERAD). ERManI codes for an enzyme that converts Man9GlcNAc to Man8GlcNAc isomer B during N-glycan biosynthesis. It also facilitates the trimming of Man5-6GlcNAc2 in the endoplasmic reticulum associated degradation pathway. Multiple transcript variants of ERManI can result from alternative splicing, and a related pseudogene can be found on chromosome 11. Research has found that mutations on the ERManI gene can result in autosomal-recessive intellectual disabilities and developmental delays (PMID: 21763484). ERManI is predominately localized to the Golgi and endoplasmic reticulum. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 3C2 |
| Isotype | IgG1 Kappa |
| Immunogen | Full length human recombinant ERManI [Swiss-Prot# Q9UKM7]. |
| Usage | |
|---|---|
| Application | WB, ELISA, IF, IHC, IP |
| Dilutions | Western Blot (1:500-1:1000); ELISA (1:1000); Immunofluorescence (1:100); Immunohistochemistry (1:200); Immunoprecipitation (1:10-1:100) |
| Reactivity | Human, Mouse |
| Validation | Knockout Validated. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Tris-Glycine (pH 7.5) and 0.15 M NaCl. |
| Preservative | 0.05% Sodium Azide |
| Storage Temp. | Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.