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EphA6 Antibody
SPA-03521
| Size | Price |
| 25 µg | Online Inquiry |
| 500 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | EphA6 |
| Gene Abbr. | EPHA6 |
| Gene ID | 285220 |
| Full Name | EPH receptor A6 |
| Alias | EHK-2, EHK2, EK12, EPA6, HEK12 |
| Introduction | EphA6, also known as Ehk2 and Hek12, is a member of the Eph receptor family which binds members of the ephrin ligand family. There are two classes of receptors, designated A and B. Both the A and B class receptors have an extracellular region consisting of a globular domain, a cysteine-rich domain, and two fibronectin type III domains. This is followed by the transmembrane region and cytoplasmic region. The cytoplasmic region contains a juxtamembrane motif with two tyrosine residues, which are the major autophosphorylation sites, a kinase domain, and a conserved sterile alpha motif (SAM) in the carboxy tail which contains one conserved tyrosine residue. Activation of kinase activity occurs after ligand recognition and binding. EphA6 has been shown to bind ephrin-A2, ephrin-A1, ephrin-A3, ephrin-A4, and ephrin-A5. |
| Product Details | |
|---|---|
| Host | Rat |
| Clonality | Monoclonal |
| Clone No. | 81605 |
| Isotype | IgG1 |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse EphA6. Met1-Gln546. Accession # Q62413. |
| Usage | |
|---|---|
| Application | WB |
| Dilutions | Western Blot (1 µg/mL) |
| Reactivity | Mouse |
| Specificity | Detects mouse EphA6 in direct ELISAs and Western Blots. In direct ELISAs, approximately 15% cross‑reactivity with recombinant rat EphB1 is observed and no cross-reactivity with recombinant human EphA1, A5, recombinant mouse EphA2, A3, A4, A7, A8, B2, B3, B4, or B6 is observed. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.