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EpCAM/TROP1 Antibody
SPA-03436
| Size | Price |
| 0.025 mL | Online Inquiry |
| 0.1 mL | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | EpCAM/TROP1 |
| Gene Abbr. | EPCAM |
| Gene ID | 4072 |
| Full Name | epithelial cell adhesion molecule |
| Alias | DIAR5, EGP-2, EGP314, EGP40, ESA |
| Introduction | The type I transmembrane glycoprotein EpCAM consists of two epidermal growth factor-like extracellular domains, a cysteine-poor region, a transmembrane domain, and a short cytoplasmic tail. EpCAM is encoded by the GA733-2 gene located on the long arm of chromosome 4. EpCAM has been described by various names, including those associated with monoclonal antibodies specific for the cell surface antigen (MH99, AUA1, MOC31, 323/A3, kS1/4, GA733, and HEA125) and cDNA clones used to define the antigen kS 1/4, EGP, EGP40, and GA733-2. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | EGP40/826 |
| Isotype | IgG1 Kappa |
| Immunogen | A synthetic peptide (around aa 20-60) from the N-terminus of human TACSTD1 protein. |
| Usage | |
|---|---|
| Application | WB, FC, IHC, IF |
| Dilutions | Western Blot (0.5-1.0 µg/mL); Flow Cytometry (0.5-1 µg/10^6 cells in 0.1 mL); Immunofluorescence (1-2 µg/mL) |
| Reactivity | Human, Mouse, Rat |
| Specificity | Recognizes a 40-43kDa transmembrane epithelial glycoprotein, identified as epithelial specific antigen (ESA), or epithelial cellular adhesion molecule (Ep-CAM). Ep-CAM is expressed on baso-lateral cell surface in most simple epithelia and a vast majority of carcinomas. This antibody has been used to distinguish adenocarcinoma from pleural mesothelioma and hepatocellular carcinoma. It is also useful in distinguishing serous carcinomas of the ovary from mesothelioma. This epithelial antigen plays an important role as a tumor-cell marker in lymph nodes from patients with esophageal carcinoma otherwise classified as node-negative. Epithelial antigen has also been suggested as a discriminator between basal cell and baso-squamous carcinomas, and squamous cell carcinoma of the skin. |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS. |
| Preservative | 0.02% Sodium Azide |
| Storage Temp. | Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.