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EpCAM/TROP1 Antibody
SPA-03435
| Size | Price |
| 0.025 mL | Online Inquiry |
| 0.1 mL | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | EpCAM/TROP1 |
| Gene Abbr. | EPCAM |
| Gene ID | 4072 |
| Full Name | epithelial cell adhesion molecule |
| Alias | DIAR5, EGP-2, EGP314, EGP40, ESA |
| Introduction | The type I transmembrane glycoprotein EpCAM consists of two epidermal growth factor-like extracellular domains, a cysteine-poor region, a transmembrane domain, and a short cytoplasmic tail. EpCAM is encoded by the GA733-2 gene located on the long arm of chromosome 4. EpCAM has been described by various names, including those associated with monoclonal antibodies specific for the cell surface antigen (MH99, AUA1, MOC31, 323/A3, kS1/4, GA733, and HEA125) and cDNA clones used to define the antigen kS 1/4, EGP, EGP40, and GA733-2. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | MOC-31 |
| Isotype | IgG1 Kappa |
| Immunogen | Neuraminidase treated GLS-1 human small cell lung carcinoma cells. |
| Usage | |
|---|---|
| Application | WB, FC, IF, IHC |
| Dilutions | Western Blot (1:100-1:200); Flow Cytometry (5-10 µL/10^6 cells in 0.1 mL) |
| Reactivity | Human, Rat |
| Specificity | Binding epitope of this antibody is located in the first EGF-like repeat domain (EGF1) between amino acids 27-59 of Ep-CAM. EGP40 is a 40-43kDa transmembrane epithelial glycoprotein, also identified as epithelial specific antigen (ESA), or epithelial cellular adhesion molecule (Ep-CAM). It is expressed on baso-lateral cell surface in most simple epithelia and a vast majority of carcinomas with the exception of adult squamous epithelium, hepatocytes and gastric epithelial cells. This antibody has been used to distinguish adenocarcinoma from pleural mesothelioma and hepatocellular carcinoma. This antibody is also useful in distinguishing serous carcinomas of the ovary from mesothelioma. |
| Storage & Handling | |
|---|---|
| Storage Buffer | 10 mM PBS with 0.05% BSA. |
| Preservative | 0.05% Sodium Azide |
| Storage Temp. | Store at 4 °C. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.