Online Inquiry
Endoglin/CD105 Antibody
SPA-03403
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | Endoglin/CD105 |
| Gene Abbr. | ENG |
| Gene ID | 2022 |
| Full Name | endoglin |
| Alias | END, HHT1, ORW1 |
| Introduction | CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2. |
| Product Details | |
|---|---|
| Host | Goat |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human Endoglin/CD105. Glu26-Gly586. Accession # Q5T9B9. |
| Usage | |
|---|---|
| Application | WB, FC, IHC, IF |
| Dilutions | Western Blot (0.25 µg/mL); Flow Cytometry (0.25 µg/10^6 cells); Immunohistochemistry (5-15 µg/mL); Immunofluorescence (5-15 µg/mL) |
| Reactivity | Human |
| Validation | Knockout Validated. |
| Specificity | Detects human Endoglin in direct ELISAs and Western Blots. In direct ELISAs, less than 15% cross-reactivity with recombinant mouse Endoglin and recombinant rat Endoglin is observed. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.