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DVL2 cDNA ORF Clone, Human, In cloning vector
SPD-04663
| Size | Price |
| 1 Unit | Online Inquiry |
| Description |
|---|
| Full length Clone DNA of Human dishevelled segment polarity protein 2 |
| Target Information | |
|---|---|
| Species | Human |
| Target Name | Dvl2 |
| Gene Abbr. | DVL2 |
| Gene ID | 1856 |
| Full Name | dishevelled segment polarity protein 2 |
| Introduction | Dishevelled (Dsh) proteins are important intermediates of Wnt signaling pathways. Dsh inhibits glycogen synthase kinase-3β promoting β-catenin stabilization. Dsh proteins also participate in the planar cell polarity pathway by acting through JNK. There are three Dsh homologs, Dvl1, Dvl2 and Dvl3 in mammals. Upon treatment with Wnt proteins, Dvls become hyperphosphorylated and accumulate in the nucleus. Dvl proteins also associate with actin fibers and cytoplasmic vesicular membranes and mediate endocytosis of the Fzd receptor after Wnt protein stimulation. Overexpression of Dvl has been reported in certain cancers. |
| Product Details | |
|---|---|
| Description | Full length Clone DNA of Human dishevelled segment polarity protein 2 |
| NCBI Ref Seq | NM_004422.2 |
| RefSeq ORF Size | 2211 bp |
| Sequence Information | Identical with the Gene Bank Ref. ID sequence except for the point mutations: 405C/T,621C/T,855G/A,1662A/G not causing the amino acid variation. |
| Vector | pUC19 Vector |
| Quality Control | The plasmid is confirmed by full-length sequencing. |
| Storage | The lyophilized plasmid can be stored at ambient temperature for three months. |
| Usage | |
|---|---|
| Sequencing Primers | M13-47 and RV-M |
| Antibiotic in E.coli | Ampicillin |
| Shipping | Each tube contains lyophilized plasmid. |
| Storage | The lyophilized plasmid can be stored at ambient temperature for three months. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.