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Dtk/Tyro3 Antibody
SPA-11559
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | Tyro3 |
| Gene Abbr. | TYRO3 |
| Gene ID | 7301 |
| Full Name | TYRO3 protein tyrosine kinase |
| Alias | BYK, Dtk, Etk-2, RSE, Rek |
| Introduction | Axl, Mer and Tyro3 are three members of the TAM family receptor tyrosine kinase that share a common NCAM (neural adhesion molecule)-related extracellular domain and a conserved intracellular tyrosine kinase domain. These receptors bind common homologous vitamin K dependent protein GAS6 and protein S to activate downstream signaling pathways. TAM family receptors are involved in the development of immune, nervous, vascular and reproductive systems, autoimmune disease, cancer drug resistance and tumor immunity response. Axl (Tyr698), Axl (Tyr702), Mer Tyr(749) and Tyro3 (Tyr681) are conserved autophosphorylation sites located in the activation loop of the respective tyrosine kinase domains. Phosphorylation at these sites is required for full kinase activation of each of the corresponding receptors. |
| Product Details | |
|---|---|
| Host | Goat |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse Tyro3/Dtk. Ala31-Ser418. Accession # P55144. |
| Usage | |
|---|---|
| Application | WB, IHC |
| Dilutions | Western Blot (0.1 µg/mL); Immunohistochemistry (5-15 µg/mL) |
| MW(KDa) | 110, 130 |
| Reactivity | Mouse |
| Specificity | Detects mouse Tyro3/Dtk in direct ELISAs and Western Blots. In direct ELISA and Western Blots, approximately 20% cross-reactivity with recombinant human (rh) Tyro3/Dtk is observed, and less than 1% cross-reactivity with recombinant mouse (rm) Axl, rmMer and rhAxl is observed. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.