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Dtk/Tyro3 Antibody
SPA-11554
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | Tyro3 |
| Gene Abbr. | TYRO3 |
| Gene ID | 7301 |
| Full Name | TYRO3 protein tyrosine kinase |
| Alias | BYK, Dtk, Etk-2, RSE, Rek |
| Introduction | Axl, Mer and Tyro3 are three members of the TAM family receptor tyrosine kinase that share a common NCAM (neural adhesion molecule)-related extracellular domain and a conserved intracellular tyrosine kinase domain. These receptors bind common homologous vitamin K dependent protein GAS6 and protein S to activate downstream signaling pathways. TAM family receptors are involved in the development of immune, nervous, vascular and reproductive systems, autoimmune disease, cancer drug resistance and tumor immunity response. Axl (Tyr698), Axl (Tyr702), Mer Tyr(749) and Tyro3 (Tyr681) are conserved autophosphorylation sites located in the activation loop of the respective tyrosine kinase domains. Phosphorylation at these sites is required for full kinase activation of each of the corresponding receptors. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | OTI2C4 |
| Isotype | IgG2B |
| Immunogen | Full length human recombinant protein of human TYRO3 (NP_006284) produced in HEK293T cell. |
| Usage | |
|---|---|
| Application | WB, IF, IHC, IP |
| Dilutions | Western Blot (1:500); Immunofluorescence (1:100); Immunohistochemistry (1:150); Immunoprecipitation (2 μg/500 µL) |
| MW(KDa) | 110, 130 |
| Reactivity | Human |
| Specificity | This antibody is specific for Homo sapiens TYRO3 protein tyrosine kinase (TYRO3). |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS (pH 7.3), 1.0% BSA and 50% Glycerol. |
| Preservative | 0.02% Sodium Azide |
| Storage Temp. | Store at -20 °C. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.