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DNMT3B Antibody
SPA-02973
| Size | Price |
| 100 µg | Online Inquiry |
| 0.025 mg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | DNMT3B |
| Gene Abbr. | DNMT3B |
| Gene ID | 1789 |
| Full Name | DNA methyltransferase 3 beta |
| Alias | ICF, ICF1, M.HsaIIIB |
| Introduction | DNA methyltransferases methylate the 5-position of cytosine in the context of CpG dinucleotides. DNA methylation is crucial for normal embryonic development, genetic imprinting, and X-chromosome inactivation. Hypermethylation of DNA has also been implicated in tumorigenesis through improper methylation of growth regulatory gene promoter regions. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | Synthetic peptide corresponding to the residues M(1) K G D S R H L N E E E G A(14) C of mouse DNMT3b. |
| Usage | |
|---|---|
| Application | WB, ChIP, IHC |
| Dilutions | Western Blot (2.0 µg/mL); Chromatin Immunoprecipitation (1:10-1:500); Immunohistochemistry (1:10-1:500) |
| Reactivity | Human, Mouse |
| Specificity | This detects DNA methyltransferase 3b (Dnmt3b) from human and mouse tissues and cells as well as recombinant human Dnmt3b. This detects, to a lesser extent, full-length human recombinant Dnmt3a. |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS with 1 mg/mL BSA. |
| Preservative | 0.05% Sodium Azide |
| Storage Temp. | Store at -20 °C. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.