DLL4 Sandwich ELISA Kit - CD BioSciences

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DLL4 Sandwich ELISA Kit

DLL4 Sandwich ELISA Kit

SPK-00261

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5 X 96T Online Inquiry
10 X 96T Online Inquiry
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Target Information
Target Name DLL4
Gene Abbr. DLL4
Gene ID 54567
Full Name delta like canonical Notch ligand 4
Alias AOS6, delta4, hdelta2
Introduction Notch signaling is activated upon engagement of the Notch receptor with its ligands, the DSL (Delta, Serrate, Lag2) proteins of single-pass type I membrane proteins. The DSL proteins contain multiple EGF-like repeats and a DSL domain that is required for binding to Notch. Five DSL proteins have been identified in mammals: Jagged1, Jagged2, Delta-like (DLL) 1, 3 and 4. Ligand binding to the Notch receptor results in two sequential proteolytic cleavages of the receptor by the ADAM protease and the γ-secretase complex. The intracellular domain of Notch is released and then translocates to the nucleus where it activates transcription. Notch ligands may also be processed in a way similar to Notch, suggesting a bi-directional signaling through receptor-ligand interactions.DLL4 expression is highly restricted to the vascular endothelium and haploinsufficiency of DLL4 results in major defects in vascular systems in mouse. Blockade of DLL4 inhibits tumor growth in model systems.
Product Details
Measurement Sandwich
Usage
Application ELISA
Reactivity
Assay Principle quantitative
Sensitivity 5.8 pg/mL
Detection Range 23.5 pg/mL - 1500 pg/mL
Sample Volume 50-100μL
Assay Time 1-5h
Detection Wavelength 450 nm
Precision Intra-assay Precision (Precision within an assay): CV%<8%.
Inter-assay Precision (Precision between assays): CV%<10%.
Storage & Handling
Storage Temp. Store at 2-8°C. Please refer to protocol.

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