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Dll1 cDNA ORF Clone, Rat, In cloning vector
SPD-04583
| Size | Price |
| 1 Unit | Online Inquiry |
| Description |
|---|
| Full length Clone DNA of Rat delta-like 1 (Drosophila). |
| Target Information | |
|---|---|
| Species | Rat |
| Target Name | DLL1 |
| Gene Abbr. | Dll1 |
| Gene ID | 84010 |
| Full Name | delta like canonical Notch ligand 1 |
| Introduction | Notch signaling is activated upon engagement of the Notch receptor with its ligands, the DSL (Delta, Serrate, Lag2) proteins of single-pass type I membrane proteins. The DSL proteins contain multiple EGF-like repeats and a DSL domain that is required for binding to Notch. Five DSL proteins have been identified in mammals: Jagged1, Jagged2, Delta-like (DLL) 1, 3 and 4. Ligand binding to the Notch receptor results in two sequential proteolytic cleavages of the receptor by the ADAM protease and the γ-secretase complex. The intracellular domain of Notch is released and then translocates to the nucleus where it activates transcription. Notch ligands may also be processed in a way similar to Notch, suggesting a bi-directional signaling through receptor-ligand interactions. |
| Product Details | |
|---|---|
| Description | Full length Clone DNA of Rat delta-like 1 (Drosophila). |
| NCBI Ref Seq | NM_032063.1 |
| RefSeq ORF Size | 2145 bp |
| Sequence Information | Identical with the Gene Bank Ref. ID sequence except for five point mutations: 250 G/C resulting in the amino acid Ala substitution by Pro, 1910 G/A resulting in the amino acid Arg substitution by Gln, 249C/G, 792 T/C, 2052 G/A not causing the amino acid variation |
| Vector | pMD18-T Simple Vector |
| Quality Control | The plasmid is confirmed by full-length sequencing. |
| Storage | The lyophilized plasmid can be stored at ambient temperature for three months. |
| Usage | |
|---|---|
| Sequencing Primers | M13-47 and RV-M |
| Antibiotic in E.coli | Ampicillin |
| Shipping | Each tube contains lyophilized plasmid. |
| Storage | The lyophilized plasmid can be stored at ambient temperature for three months. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.