Cat#: CCR-0005
TCO PEG4 succinimidyl ester
Synonyms (s): trans-Cyclooctene-PEG4-NHS
Empirical Formula (Hill Notation): C24H38N2O10
Size: 5 mg; 25 mg
Product Introduction
| Molecular Weight | 514.57 |
| NACRES | NA.22 |
| MDL Number | MFCD28118912 |
| PubChem Substance ID | 329768214 |
| Form | Liquid |
| Reaction Suitability | Reaction type: click chemistry |
| Smiles String | O=C(NCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)OC2CCC/C=C/CC2 |
| InChI | 1S/C24H38N2O10/c27-21-8-9-22(28)26(21)36-23(29)10-12-31-14-16-33-18-19-34-17-15-32-13-11-25-24(30)35-20-6-4-2-1-3-5-7-20/h1-2,20H,3-19H2,(H,25,30)/b2-1+ |
| InChI key | ZKPMRASGLDBKPF-OWOJBTEDSA-N |
| Storage Temp. | -20 °C |
Application
Succinimidyl ester/NHS (amine reactive) functionalized trans-cyclooctene derivative for incorporation of the cyclooctene moiety into amine containing compounds or biomolecules. Trans-cyclooctenes are useful in strain-promoted, copper-free, click chemistry cycloaddition reactions with 1, 2, 4, 5-tetrazines. This cyclooctene will react with tetrazine functionalized compounds or biomolecules, without the need for a catalyst, to result in a stable covalent linkage. The 4+2 inverse electron demand Diels-Alder cycloaddition between trans-cyclooctene and tetrazines is the fastest biologically compatible ligation technology reported, and has had many applications in biological labeling and imaging. The PEG spacer allows for increased water solubility, less aggregation, and an increased distance between the amine to be modified and the reactive alkene.
Safety Information
| Storage Class Code | 11 - Combustible Solids |
| WGK | WGK 3 |
For research use only. Not for clinical use.
