Cat#: CCR-0078
TCO-amine HCl salt
Synonyms (s): trans-Cyclooctene-amine hydrochloride salt, TCO-NH2, HCl salt
Empirical Formula (Hill Notation): C12H22N2O2 · HCl
Size: 10 mg; 50 mg
Product Introduction
| Molecular Weight | 262.78 |
| NACRES | NA.22 |
| PubChem Substance ID | 329768216 |
| Form | Solid |
| Reaction Suitability | Reaction type: click chemistry |
| Smiles String | O=C(NCCCN)OC1CCC/C=C/CC1.[H]Cl |
| InChI | 1S/C12H22N2O2.ClH/c13-9-6-10-14-12(15)16-11-7-4-2-1-3-5-8-11;/h1-2,11H,3-10,13H2,(H,14,15);1H/b2-1+; |
| InChI key | GIYQQURLGCGUKK-TYYBGVCCSA-N |
| Storage Temp. | -20 °C |
Application
Amine functionalized trans-cyclooctene derivative for incorporation of the cyclooctene moiety into carboxyl containing compounds or biomolecules via standard coupling techniques (DCC; EDC etc...). Trans-cyclooctenes are useful in strain-promoted copper-free click chemistry cycloaddition reactions with 1; 2; 4; 5-tetrazines. This cyclooctene will react with tetrazine functionalized compounds or biomolecules without the need for a catalyst to result in a stable covalent linkage. The 4+2 inverse electron demand Diels-Alder cycloaddition between trans-cyclooctene and tetrazines is the fastest biologically compatible ligation technology reported and has had many applications in biological labeling and imaging.
Safety Information
| Signal Word | Warning |
| Hazard Classifications | H302 |
| Storage Class Code | 11 - Combustible Solids |
| WGK | WGK 3 |
For research use only. Not for clinical use.
