Stem Cell Delivery

Dendrimers are highly branched, nanoscale polymers that have attracted significant interest in biomedical applications due to their unique chemical and physical properties. One potential application of dendrimers is in stem cell therapy delivery. Stem cell therapy is a promising approach for treating a variety of diseases and injuries, but one of the challenges of stem cell therapy is delivering the cells to the site of injury or disease in a safe and effective manner. Dendrimers can be used to encapsulate stem cells and protect them from the harsh environment of the body, as well as to target the cells to specific tissues or organs.

Overview of Stem Cell Therapy

Stem cell therapy is a rapidly developing field of medicine that offers great promise for treating a variety of diseases and conditions. Stem cells are undifferentiated cells that have the ability to develop into various types of specialized cells, such as muscle, bone, or nerve cells. There are two main types of stem cells: embryonic stem cells, which are obtained from human embryos, and adult stem cells, which are found in various tissues throughout the body, such as bone marrow, fat, and skin. Stem cell therapy involves using these cells to replace or repair damaged or diseased tissues in the body. Despite these challenges, stem cell therapy has shown promise in a number of clinical trials and is being actively researched for a wide range of conditions, including Parkinson's disease, diabetes, spinal cord injuries, and heart disease.

Biomedical Materials for Stem Cell Delivery

Biomedical materials play a critical role in stem cell therapy delivery, providing a platform for the delivery and localization of stem cells to the site of injury or disease. These materials can be classified into two main categories: natural and synthetic materials.

• Natural Materials
  Natural materials include extracellular matrix (ECM) proteins such as collagen, fibronectin, and laminin. ECM proteins provide a biological environment that supports stem cell attachment, migration, and differentiation. In addition to ECM proteins, natural materials such as alginate, chitosan, and hyaluronic acid have also been used as hydrogels for stem cell delivery.
• Synthetic Materials
  Synthetic materials include polymers such as polyethylene glycol (PEG), poly (lactic-co-glycolic acid) (PLGA), and poly(caprolactone) (PCL). Synthetic materials offer advantages such as control over mechanical properties, degradation rate, and release of bioactive molecules. These properties can be tailored to optimize stem cell delivery and tissue regeneration.

Advantages of Dendrimer as a Synthetic Material in Stem Cell Delivery

One advantage of using dendrimers for stem cell therapy delivery is that they can be designed with precise control over their size, shape, and surface chemistry. This allows for the creation of dendrimers with specific properties that can enhance their interactions with stem cells and improve their delivery to target tissues.

Another advantage of dendrimers is their biocompatibility and low toxicity. Dendrimers are typically made from biocompatible materials such as polyethylene glycol (PEG) or polyamidoamine (PAMAM), which reduces the risk of adverse reactions in the body.

An Overview of dendrimer-mediated therapeutics and gene delivery into stem cells. (Pishavar E, et al., 2021)

How We Can Help

As a fast-growing biotechnology company offering customized services, CD BioSciences is committed to providing high quality dendrimer products and services to customers worldwide to assist with their attractive dendrimer research projects. All our deliverables will be subject to rigorous quality testing and delivered on time. If you are interested in our services or have any other questions, please do not hesitate to contact us.

Reference

1. Pishavar E.; et al. Recent advances of dendrimer in targeted delivery of drugs and genes to stem cells as cellular vehicles. Biotechnol Prog. 2021, 37: e3174.