Cat#: CLP-0001
Propargyl-N-hydroxysuccinimidyl ester
Synonyms (s): 2,5-Dioxopyrrolidin-1-yl 3-(prop-2-ynyloxy)propanoate, 3-(2-Propyn-1-yloxy)propanoic acid 2,5-dioxo-1-pyrrolidinyl ester, Alkyne-NHS ester, Propargyl-succinimidyl-ester
Empirical Formula (Hill Notation): C10H11NO5
Size: 50 mg; 250 mg
Product Introduction
| Molecular Weight | 225.2 |
| CAS Number | 1174157-65-3 |
| MDL Number | MFCD13184973 |
| PubChem Substance ID | 329767108 |
| Form | Solid |
| Reaction Suitability | Reaction type: Biotinylations; Reaction type: Biotinylations; Reactivity: amine reactive |
| Smiles String | C#CCOCCC(ON1C(CCC1=O)=O)=O |
| InChI | 1S/C10H11NO5/c1-2-6-15-7-5-10(14)16-11-8(12)3-4-9(11)13/h1H,3-7H2 |
| InChI key | WKIKHHMUNOVQLD-UHFFFAOYSA-N |
| Storage Temp. | -20 °C |
Application
Propargyl-N-hydroxysuccinimidyl ester may be used as a tool for identifying nucleophilic ligandable hotspots by chemoproteomic approaches.
Propargyl-NHS ester is an amine reactive reagent for derivatizing peptides, antibodies, amine coated surfaces etc, with a terminal alkyne. The alkyne can be reacted with an azide containing compound or biomolecule via copper catalyzed azide-alkyne click chemistry to yield a stable triazole linkage.
Safety Information
| Storage Class Code | 13 - Non Combustible Solids |
| WGK | WGK 3 |
For research use only. Not for clinical use.
