N-(But-3-yn-1-yl)-2-(((2-oxo-2H-chromen-7-yl)oxy)methyl)acrylamide

Synonyms (s): Coumarin alkyne CoLDR probe

Empirical Formula (Hill Notation): C₁₇H₁₅NO₄

Size: 50 mg; 100 mg

Product Introduction

Molecular Weight	297.31
Reaction Suitability	Reagent type: chemical modification; Reagent reaction type: click chemistry
Smiles String	O=C1OC2=CC(OCC(C(NCCC#C)=O)=C)=CC=C2C=C1
Storage Temp.	2-8 °C

Application

N-(But-3-yn-1-yl)-2-(((2-oxo-2H-chromen-7-yl)oxy)methyl)acrylamide is a proteomic cysteine probe. As described in Reddi et al, the Nir London lab developed a-substituted N-alkynyl-methacrylamides for covalent ligand directed release chemistry (CoLDR). CoLDR represents a new type of acrylamide-based electrophiles for targeted covalent inhibitor discovery and design. Specifically this CoLDR probe is a coumarin derivative with a terminal alkyne for click chemistry.

Safety Information

Storage Class Code	11 - Combustible Solids
WGK	WGK 3

For research use only. Not for clinical use.