Cat#: CLP-0028
Methyltetrazine-NHS ester
Empirical Formula (Hill Notation): C15H13N5O4
Size: 100 mg
Product Introduction
| Molecular Weight | 327.29 |
| NACRES | NA.22 |
| CAS Number | 1644644-96-1 |
| MDL Number | MFCD28334557 |
| Assay | ≥95% |
| Form | Powder or Crystals |
| Reaction Suitability | Reaction type: Click chemistry; Reagent type: Cross-linking reagent |
| Smiles String | O=C(ON1C(CCC1=O)=O)CC(C=C2)=CC=C2C3=NN=C(C)N=N3 |
| Storage Temp. | -20 °C |
Application
Methyltetrazine-NHS ester has an N-hydroxysuccinimide (NHS) ester that can be reacted with primary amines and a methyltetrazine, which is reactive to trans-cyclooctenes. The NHS ester reacts with primary amines (e.g. side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic pH to form covalent bonds. The short spacer arm adds minimal mass to modified molecules (230.2 daltons). It is generally used in click chemistry applications in bioconjugate chemistry.
Safety Information
| Storage Class Code | 11 - Combustible Solids |
| WGK | WGK 3 |
For research use only. Not for clinical use.
