Immune Cell Delivery

Immune cell therapy, also known as cellular immunotherapy, is a type of cancer treatment that uses the body's own immune system to fight cancer. Dendritic cells are a type of immune cell that plays a crucial role in activating and directing the immune response against cancer cells. However, one of the challenges of dendritic cell therapy is delivering the dendritic cells to the tumor site in sufficient numbers to elicit a therapeutic response. This is where dendrimers come in - they can be used to deliver dendritic cells to the tumor site more efficiently.

Introduction into Immune Cell Therapy

Immune cell therapy is a type of cancer treatment that uses a patient's own immune system to fight cancer. It involves modifying or enhancing the immune cells, such as dendritic cells, and then infusing them back into the patient's body to target and destroy cancer cells. One form of immune cell therapy is CAR-T cell therapy, which involves genetically modifying a patient's T-cells to recognize and attack cancer cells. The modified T-cells are then infused back into the patient's body, where they can seek out and destroy cancer cells. Another form of immune cell therapy is called adoptive cell transfer, which involves removing immune cells from a patient's body, modifying them in the laboratory, and then infusing them back into the patient's body to target cancer cells.

Application of Nanomaterials in Immune Cell Therapy

Nanomaterials have shown potential as a tool for improving immune cell therapy. The use of nanomaterials in this context involves designing and engineering nanoparticles that can interact with immune cells to enhance their therapeutic effects.

• Delivering of Antigens
  One approach is to use nanoparticles to deliver antigens to immune cells. These nanoparticles can be designed to target immune cells specifically, allowing for a more efficient delivery of antigens. By delivering antigens directly to immune cells, this approach can increase the number of T cells that are activated in response to the antigens, potentially improving the effectiveness of immune cell therapy.
• Modulating the Immune Response
  Another approach is to use nanoparticles to modulate the immune response. Nanoparticles can be engineered to release molecules that enhance or suppress the immune response, depending on the therapeutic goal. For example, nanoparticles can be designed to release molecules that promote the proliferation of T cells or to inhibit the activity of immune-suppressive cells, such as regulatory T cells.
• Improving in Vivo Imaging
  Nanoparticles can also be used to improve the imaging of immune cells in vivo, allowing for more accurate monitoring of the immune response. This can help to identify which patients are responding to immune cell therapy and which patients may need alternative treatments.

Dendrimer as a Nanomaterial for Dendritic Cell Delivery

Dendrimers are a class of nanomaterials that have been extensively investigated for drug delivery and therapeutic applications. Dendrimers have a highly branched dendritic structure, making them highly versatile in terms of chemical composition, size, and surface properties. One potential application of dendrimers in immune cell therapy is dendritic cell therapy, a type of cancer immunotherapy that involves the use of a patient's own immune cells to fight cancer. Dendritic cells are a type of immune cell that plays a key role in activating and directing the immune response against cancer cells. One of the challenges of dendritic cell therapy is to deliver dendritic cells to the tumor site in sufficient numbers to elicit a therapeutic response. This is where dendrimers come in - they can be used to deliver dendritic cells to the tumor site more efficiently. Dendrimers can be functionalized with a variety of ligands and targeting molecules that allow them to selectively bind to and enter dendritic cells. In addition, dendrimers can be loaded with drugs, peptides, or other therapeutic agents to help enhance the immune response to cancer cells.

Nanoparticle-based strategies for dendritic cell (DC) vaccination progress. (Hashemi V, et al., 2020)

How We Can Help

CD BioSciences has highly trained, friendly, and professional study directors and project managers dedicated to completing your attractive dendrimer research project on time. A wealth of experience and advanced technology ensures that CD BioSciences provides a high quality, hassle-free and bespoke services for your dendrimer research project. We also have a range of innovative dendrimer products to meet your different experimental needs. If you are interested in our services or have any other questions, please do not hesitate to contact us.

Reference

1. Hashemi V.; et al. Nanomedicine for improvement of dendritic cell-based cancer immunotherapy. Int Immunopharmacol. 2020, 37: e3174.