Cat#: CCR-0049
Dibenzocyclooctyne-sulfo-N-hydroxysuccinimidyl ester
Synonyms (s): DBCO-sulfo-NHS ester, DBCO-sulfo-SE
Empirical Formula (Hill Notation): C25H21N2NaO8S
Size: 1 mg; 5 mg
Product Introduction
| Molecular Weight | 532.50 |
| NACRES | NA.22 |
| MDL Number | MFCD22572669 |
| PubChem Substance ID | 329766600 |
| Form | Solid |
| Reaction Suitability | Reaction type: click chemistry |
| Smiles String | O=C(CCCCC(ON(C(CC1S(=O)(O[Na])=O)=O)C1=O)=O)N2CC3=C(C=CC=C3)C#CC4=C2C=CC=C4 |
| InChI | 1S/C25H22N2O8S.Na/c28-22(11-5-6-12-24(30)35-27-23(29)15-21(25(27)31)36(32,33)34)26-16-19-9-2-1-7-17(19)13-14-18-8-3-4-10-20(18)26;/h1-4,7-10,21H,5-6,11-12,15-16H2,(H,32,33,34);/q;+1/p-1 |
| InChI key | QXKHPYSXPCJSPR-UHFFFAOYSA-M |
| Storage Temp. | -20 °C |
Application
Water soluble succinimidyl ester/NHS functionalized cyclooctyne derivative for incorporation of the cyclooctyne moiety into amine containing compounds or biomolecules. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.
Dibenzocyclooctyne-sulfo-N-hydroxysuccinimidyl ester may be used for the covalent modification of nano-sized metal-organic frameworks (NMOFs) with nucleic acids via click chemistry during the synthesis stimuli-responsive DNA-gated NMOFs. These NMOFs can act as carriers of a fluorescent agent or anticancer drug, making them highly useful in targeted drug release system.
Safety Information
| Storage Class Code | 11 - Combustible Solids |
| WGK | WGK 3 |
For research use only. Not for clinical use.
