Cat#: CCR-0039
Dibenzocyclooctyne-PEG4-N-hydroxysuccinimidyl ester
Synonyms (s): DBCO-PEG4-NHS ester, DBCO-PEG4-SE, DBCO-PEG4-succinimidyl ester
Empirical Formula (Hill Notation): C34H39N3O10
Size: 1 mg; 5 mg
Product Introduction
| Molecular Weight | 649.69 |
| NACRES | NA.22 |
| MDL Number | MFCD26793797 |
| PubChem Substance ID | 329767092 |
| Assay | 95% |
| Form | Paste |
| Reaction Suitability | Reaction type: click chemistry |
| Smiles String | O=C(CCC(NCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)=O)N2CC3=C(C=CC=C3)C#CC4=C2C=CC=C4 |
| InChI | 1S/C34H39N3O10/c38-30(11-12-31(39)36-25-28-7-2-1-5-26(28)9-10-27-6-3-4-8-29(27)36)35-16-18-44-20-22-46-24-23-45-21-19-43-17-15-34(42)47-37-32(40)13-14-33(37)41/h1-8H,11-25H2,(H,35,38) |
| InChI key | RRCXYKNJTKJNTD-UHFFFAOYSA-N |
| Storage Temp. | -20 °C |
Application
Dibenzocyclooctyne-PEG4-N-hydroxysuccinimidyl ester may be used in the synthesis of a prostate-specific membrane antigen (PSMA)-targeted single photon emission computed tomography (SPECT) agent via copper-less click chemistry.
Succinimidyl ester (NHS, amine reactive) functionalized cyclooctyne derivative for incorporation of the cyclooctyne moiety into amine containing compounds or biomolecules. Cyclooctynes are useful in strain-promoted copper-free click chemistry cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage. Applications Include: Protein-peptide conjugatesAntibody-enzyme or antibody-drug conjugatesProtein or peptide-oligonucleotide conjugates Surface modification
Safety Information
| Storage Class Code | 11 - Combustible Solids |
| WGK | WGK 3 |
For research use only. Not for clinical use.
