Cat#: CLP-0050
Dibenzocyclooctyne-N-hydroxysuccinimidyl ester
Synonyms (s): DBCO-NHS ester, DBCO-SE
Empirical Formula (Hill Notation): C23H18N2O5
Size: 5 mg; 50 mg
Product Introduction
| Molecular Weight | 402.40 |
| NACRES | NA.22 |
| MDL Number | MFCD24386367 |
| PubChem Substance ID | 329766555 |
| Form | Solid |
| Reaction Suitability | Reaction type: Click chemistry; Reagent type: Cross-linking reagent |
| Smiles String | O=C(CCC(ON(C(CC1)=O)C1=O)=O)N2CC3=C(C=CC=C3)C#CC4=C2C=CC=C4 |
| InChI | 1S/C23H18N2O5/c26-20(13-14-23(29)30-25-21(27)11-12-22(25)28)24-15-18-7-2-1-5-16(18)9-10-17-6-3-4-8-19(17)24/h1-8H,11-15H2 |
| InChI key | XCEBOJWFQSQZKR-UHFFFAOYSA-N |
| Storage Temp. | -20 °C |
Application
Succinimidyl ester (NHS, amine reactive) functionalized cyclooctyne derivative for incorporation of the cyclooctyne moiety into amine containing compounds or biomolecules. Cyclooctynes are useful in strain-promoted copper-free click chemistry cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage. Applications Include: Protein-peptide conjugatesAntibody-enzyme or antibody-drug conjugatesProtein or peptide-oligonucleotide conjugates Surface modification
Safety Information
| Storage Class Code | 13 - Non Combustible Solids |
| WGK | WGK 3 |
For research use only. Not for clinical use.
