Dentistry

Dendrimers are highly branched, monodisperse macromolecules with a unique architecture that makes them attractive for a wide range of biomedical applications. In dentistry, dendrimers have shown promising potential in several areas. Dendrimers show great promise in the field of dentistry and have the potential to revolutionize the way we approach dental treatments and oral hygiene.

Introduction into Polymers in Dentistry

Polymers have been used in dentistry for many years due to their favorable properties, such as biocompatibility, mechanical strength, and ease of processing. The selection of a particular polymer depends on the specific application and the desired properties. Some common polymers used in dentistry include:

• Polyethylene
  Polyethylene is used in dentistry for the fabrication of implant abutments and denture teeth. It has good wear resistance and biocompatibility.
• Polycarbonate
  Polycarbonate is a strong, transparent polymer used in dentistry for orthodontic retainers and splints.
• Polyetheretherketone (PEEK)
  PEEK is a high-performance polymer that is used in dentistry for the fabrication of dental implants, abutments, and bridges. It has excellent mechanical properties, biocompatibility, and resistance to wear and corrosion.
• Polyvinyl siloxane (PVS)
  PVS is a type of silicone polymer used in dentistry for impression materials. It is biocompatible, has good flow properties, and provides accurate impressions.
• Polylactic acid (PLA)
  PLA is a biodegradable polymer used in dentistry for the fabrication of resorbable sutures and bone graft substitutes.
• Poly (methyl methacrylate) (PMMA)
  PMMA is a widely used polymer in dentistry, commonly used in the fabrication of denture bases, temporary crowns, and bridges. It is biocompatible, easy to process, and has good mechanical properties.

Applications of Dendrimers In Dentistry

• Drug Delivery
  Dendrimers are versatile drug delivery vehicles due to their unique structure and size. They can be functionalized with different types of drugs, such as antibiotics, analgesics, and anti-inflammatory agents, and can be targeted to specific areas in the oral cavity. Additionally, dendrimers have been investigated for their potential use in targeted drug delivery for oral cancer treatment.
• Dental Adhesives
  Dendrimers have been incorporated into dental adhesives to improve their bonding strength and durability. Dendrimers can create a high degree of crosslinking within the adhesive, which improves its mechanical properties and reduces its degradation over time.
• Anti-microbial Agents
  Dendrimers have been functionalized with various types of antimicrobial agents, such as chlorhexidine and silver ions, to create sustained release formulations. These formulations can be used for the treatment of oral infections, such as dental caries and periodontal disease.
• Dental Implants
  Dendrimers have been used to modify the surface of dental implants to improve their biocompatibility and reduce the risk of implant failure. Dendrimers have also been investigated for their potential use in implant coatings that reduce bacterial colonization and infection.
• Cavity Prevention
  Dendrimers have been incorporated into dental materials, such as dental composites and glass ionomer cements, to improve their mechanical properties and release fluoride ions for cavity prevention. The use of dendrimers in these materials can lead to stronger and more durable restorations, as well as reduced risk of secondary caries.

Remineralisation of demineralised dentin by dendrimers. (Bapat RA, et al., 2019)

How We Can Help

CD BioSciences has been dedicated to dendrimer research for many years, providing innovative products and high-quality services to meet the needs of our customers for a wide range of dendrimer applications. We have a professional technical team and advanced platform to help our customers overcome difficult problems. If you are interested in our services, please contact us and tell us about your project.

References

1. Bapat RA.; et al. The potential of dendrimer in delivery of therapeutics for dentistry. Drug Deliv Transl Res. 2019, 5: e02544.
2. Dave K.; et al. Dendritic polymers for dermal drug delivery. Ther Deliv. 2017, 8: 1077-1096.