Dendrimer Molecular Weight Determination Service

Molecular weight is a key property of chemicals, especially for polymers. CD BioSciences has extensive experience and sophisticated tools for measuring the molecular weight of all types of compounds and polymers, especially dendrimers. We are confident that our molecular weight measurement services for dendrimers will help our customers advance new product development and material selection and address barriers to the application of dendrimers.

Significance of Dendrimer Molecular Weight Determination

The molecular weight of proteins, synthetic and natural polymers is a direct indicator of product performance and activity. As the fourth class of polymers, dendrimers are also the newest class of polymers with well-defined monodispersity and homogeneous molecular structure. Dendrimers differ from other classical polymers due to symmetry, high branching, and maximum terminal functional density. Molecular weight determination of polymers is critical for product development, continued processing/generation during the polymer life cycle, and for delivering product performance. For example, high molecular weight affects the brittleness and tensile strength of the polymer and low molecular weight affects the melt processing ability of the polymer. Thus, as a class of polymers, the properties and performance of dendrimers are influenced by molecular weight. There are many techniques used for molecular weight determination of dendrimers, such as chromatography, mass spectrometry and scattering techniques.

Molecular weight determination of PAMAM dendrimers by mass spectrometry. (Lloyd JR, et al., 2016)

Technologies for Dendrimer Molecular Weight Determination

• Spectroscopic Techniques
  Mass Spectrometry (MS): As an analytical technique, MS can be used to determine the molecular weight, structural defects, and purity of dendrimers, and it also allows for the confirmation of monomeric assemblies in branches from fragmentation patterns.

Fluorescence Spectroscopy: Fluorescence spectroscopy can be used to determine not only the size and shape of dendrimers, but also valuable information about their interactions with drugs.

• Chromatographic Techniques
  Chromatographic techniques include mainly gel permeation chromatography (GPC) and high-performance liquid chromatography (HPLC).
• Scattering Techniques
  Scattering techniques including small angle neutron scattering (SANS), quasi-elastic neutron scattering (QENS), small-angle x-ray scattering (SAXS) and dynamic light scattering (DLS) are essential for dendrimer characterization assays and can be used to determine the structure, conformation, shape, and kinetic characteristics of dendrimers.

Our Services

Because dendrimers undergo raw material, molding, sterilization and storage stages, their molecular weights may change during their life cycle. With sophisticated equipment, expertise, and experience, CD BioSciences provides dendrimer molecular weight determination services to customers worldwide. Our tests, insights and recommendations help you make decisions and help ensure product integrity. Our state-of-the-art laboratories advance new dendrimer product development and material selection by helping you achieve dendrimer molecular weight determination.

• Spectroscopic Techniques for Dendrimer Molecular Weight Determination
  CD BioSciences offers you techniques for dendrimer molecular weight detection mainly by MS (e.g., electron impact, fast atom bombardment and matrix-assisted laser desorption ionization mass spectrometry) and fluorescence spectroscopy.
• Chromatographic Techniques for Dendrimer Molecular Weight Determination
  With sophisticated equipment, CD BioSciences offers global customers the service of detecting the molecular weight of dendrimers by chromatographic techniques.
• Scattering Techniques for Dendrimer Molecular Weight Determination
  CD BioSciences offers customers scattering techniques for the detection of dendrimers, mainly SANS.

Service Process

Want to Learn More?

As experts in the study of dendrimers, CD BioSciences not only has innovative dendrimer products, but also provides high-quality, hassle-free, cost-effective dendrimer molecular weight determination services to customers worldwide. With expert knowledge and sophisticated equipment, our experienced scientists are confident in delivering results to your satisfaction. If you are interested in our services or have any other questions, please feel free to contact us.

Reference

1. Lloyd JR, et al., Characterization of Polyamidoamino (PAMAM) Dendrimers Using In-Line Reversed Phase LC Electrospray Ionization Mass Spectrometry. Anal Methods. 2016, 14: 263-269.