Dendrimer-Lectin Conjugation Service

Glycopeptide dendrimers conjugated with lectins can inhibit the formation of bacterial biofilms and achieve antimicrobial effects. As a fast-growing custom service provider, CD BioSciences is confident to provide you with dendrimer-lectin conjugation services to meet your every detailed requirement and help you advance your project because of our years of experience in dendrimer research.

Introdution into Lectins

The spread of resistant bacteria is one of the most pressing issues in human health today, with ubiquitous Gram-negative bacteria infecting patients with impaired and cystic fibrosis and causing fatal airway infections. The development of bacterial resistance is associated with the formation of biofilms. With the formation of bacterial colonies attached to biotic or abiotic surfaces, the process of biofilm formation, the bacteria form a physical barrier against antibiotics, which leads to the development of bacterial resistance. The process of breaking the formation of bacterial biofilm can restore the susceptibility of bacteria to antibiotics to overcome resistance. The formation of biofilm is mediated by lectins. Lectins are widespread in nature and act as carbohydrate-binding proteins with specific but usually weak binding sites whose potency is increased by multivalency, leading to the so-called clustering effect. The multivalency of lectins can occur on the side of the lectin or on the side of the glycosidic ligand. In addition, lectins do not possess enzymatic activity but also mediate bacterial, viral, and fungal attachment.

Dendrimer-Lectin Conjugation Inhibits Biofilm Formation

As a carbohydrate-binding protein, lectins are highly specific for the glycosyl groups of many biomolecules and can cause agglutination of specific cells or precipitation of glycoconjugates and polysaccharides. Lectins have recognition roles at the cellular and molecular levels and play many roles in biological recognition phenomena involving cells, carbohydrates, and proteins. Dendrimers are regularly branched synthetic macromolecules with a highly branched three-dimensional structure whose properties and size can be precisely controlled. Dendrimers are particularly well suited for multivalent display of chemical groups and show useful properties for a wide range of applications. When dendrimers multivalently display carbohydrates, they can bind to lectins, thereby preventing the formation of bacterial biofilms and reducing the development of bacterial drug resistance.

Models of glycopeptide dendrimer lectin complexes obtained from molecular dynamics (MD) simulations. (Michaud G, et al., 2016)

Our Services

As a rapidly growing, leading global provider of scientific research services and solutions, CD BioSciences has established relationships with millions of researchers worldwide. With years of experience in dendrimer modification, our extensive experience gives us the confidence to provide you with dendrimer-lectin conjugate modification services. Our talented scientists will meet all your detailed requirements and provide you with the best solution to advance your project in a timely manner.

Why Choose CD BioSciences?

• We have a comprehensive and proven dendrimer modification platform that allows us to tailor solutions to our clients' specific objectives and ensure that all deliverables are rigorously validated.

• Our talented scientists have extensive experience and expertise in organic chemistry and can provide timely solutions to advance project research based on each specific customer request.

• Based on our strong platform resources in dendrimer research, CD BioSciences can provide customized services to dendrimer researchers around the world and help clients solve almost any difficulties encountered in their project research.

Service Process

Want to Learn More?

CD BioSciences is committed to helping our customers meet the growing and evolving demand for dendrimer products. We offer a wide range of services related to dendrimers, providing you with excellent solutions in a timely manner to help you carry out your research projects. If you are interested in our services or have any additional questions, please feel free to contact us, we are happy to hear from you and look forward to working with you.

Reference

1. Michaud G.;et al. Overcoming antibiotic resistance in Pseudomonas aeruginosa biofilms using glycopeptide dendrimers. Chem Sci. 2016, 7: 166-182.