Dendrimer-Fluorophore Conjugation Service

Conjugated with dendrimers, fluorophores not only improve their transfection efficiency, but also allow for a wide range of biomedical applications. CD BioSciences provides high-quality, customized services to researchers worldwide, developing effective strategies to solve all problems encountered in the modification of dendrimers.

Introduction into Fluorophores

A fluorophore, also known as a fluorescent dye, is similar to a chromophore and acts as a fluorescent compound that can re-emit when excited by light, usually containing several combined aromatic groups, or planar or cyclic molecules with multiple π bonds. Fluorophores are fluorescent dyes that can be used as fluorescent markers for protein, tissue, and cellular labeling for detection by fluorescence microscopy. Fluorophores have a variety of applications and can be used as tracers in liquids, as dyes for staining certain structures, as substrates for enzymes or as probes.

Dendrimer-Fluorophore Conjugation for Gene Transfection

Structure of fluorophores-modified dendrimer.
(Tambe V, et al., 2017)

A dendrimer is a hyperbranched macromolecule that acts as a polymer and is formed by the conjugation of monomers. Dendrimers are synthesized stepwise, allowing perfect control over the three-dimensional structure, shape, size, number, and type of terminal functional groups of the molecule. Most dendrimers are organic, consisting of C, H, N, O, and usually have a nitrogen atom at the branching point. However, other types of dendrimers exist, particularly phosphorus and silicon-phosphorus-containing dendrimers, which are important for nanomaterials and nanomedicines, mainly because their terminal functional groups can be easily modified starting from the "native" terminal functions which are either aldehydes or P(S)Cl2 groups. The fluorescent groups can be located as terminal groups on the surface, or at the core, or linked to the core (off-center) or to the branches of the dendritic structure. Dendrimers modified by fluorophores are mainly used in gene transfection, not only to display the vector during transfection, but also to improve transfection efficiency.

Our Services

As a biotechnology company specializing in dendrimer modification and product development, CD BioSciences provides cost-effective, high-quality, and hassle-free dendrimer-fluorophore conjugation services to customers worldwide. With our sophisticated equipment and advanced technology, we are confident that we can assist you with every dendrimer-fluorophore conjugation service, overcoming project challenges with the fastest turnaround time. Our services include but are not limited to.

Advantages of Our Services

Experienced team of scientists and technicians to support you from the beginning to the end of your project.

Customized services for your attractive projects to meet your exact needs.

Timely response and continuous communication with fast turnaround times.

High quality service and assurance that all results are subject to rigorous quality testing.

Want to Learn More?

As a leading global provider of custom services, CD BioSciences has been specializing in dendrimer modification and products development. With sophisticated equipment and experienced scientists, we are confident that we can meet every specific requirement of your project and deliver on-time results that have undergone a rigorous quality testing process. If you are interested in our services or have any other questions, please feel free to contact us.

Reference

1. Tambe V, et al., Surface Engineered Dendrimers in siRNA Delivery and Gene Silencing. Curr Pharm Des. 2017, 23: 2952-2975.