Dendrimer-Ciprofloxacin Conjugation Service

One of the advantages of dendrimer-ciprofloxacin conjugates is their ability to selectively target bacterial cells while minimizing damage to healthy cells. Over the years, CD BioSciences has dedicated itself to dendrimer-related research and has accumulated extensive experience with innovative dendrimer products and advanced technology platforms. Our dedicated scientists are confident to provide you with dendrimer-ciprofloxacin conjugation services to reduce drug resistance.

Introduction into Ciprofloxacin

Ciprofloxacin is an antibiotic medication that belongs to the fluoroquinolone class of drugs. It is used to treat a wide range of bacterial infections, including urinary tract infections, respiratory tract infections, skin and soft tissue infections, bone and joint infections, and certain types of gastrointestinal infections. Ciprofloxacin works by inhibiting the bacterial DNA gyrase enzyme, which is necessary for bacterial DNA replication and transcription. By blocking this enzyme, ciprofloxacin prevents the growth and multiplication of bacteria, allowing the body's immune system to effectively fight off the infection.

Methods of Dendrimer-Ciprofloxacin Conjugation

Ciprofloxacin is a broad-spectrum antibiotic that is commonly used to treat bacterial infections. However, it has some limitations such as low solubility and poor bioavailability. Dendrimer-ciprofloxacin conjugation is a strategy to overcome these limitations and enhance the efficacy of ciprofloxacin. The conjugation of ciprofloxacin to dendrimers can be achieved by various methods such as covalent bonding, electrostatic interaction, and encapsulation. Covalent bonding involves the formation of a stable chemical bond between the dendrimer and ciprofloxacin, while electrostatic interaction relies on the attraction between positively charged dendrimers and negatively charged ciprofloxacin molecules. Encapsulation involves the entrapment of ciprofloxacin molecules within the dendrimer structure.

Structures of the active molecule ciprofloxacin, PAMAM dendrimer and ciprofloxacin-dendrimer conjugate. (Svenningsen SW, et al., 2020)

Advantages of Dendrimer-Ciprofloxacin Conjugation

Dendrimer-ciprofloxacin conjugates have shown promising results in improving the solubility, stability, and bioavailability of ciprofloxacin. They have also demonstrated enhanced antibacterial activity against various bacterial strains. Additionally, dendrimer-ciprofloxacin conjugates have shown improved cellular uptake and retention, making them attractive for intracellular infections.

• Increase Targeting
  One of the advantages of dendrimer-ciprofloxacin conjugates is their ability to selectively target bacterial cells while minimizing damage to healthy cells. This is achieved by utilizing the unique properties of dendrimers, such as their ability to penetrate bacterial biofilms and target intracellular bacteria. Dendrimers can also protect the conjugated drug from degradation by enzymes and enhance its stability in biological fluids.
• Reduce Medicine Resistance
  In addition to improving the pharmacokinetic properties of ciprofloxacin, dendrimer-ciprofloxacin conjugates have also been shown to reduce the development of antibiotic resistance. This is because dendrimers can prevent the formation of biofilms, which are known to contribute to antibiotic resistance by providing a protective environment for bacteria to grow and reproduce.
• Improve Efficacy
  The method of conjugation can also influence the properties and efficacy of dendrimer-ciprofloxacin conjugates. For example, covalent bonding can provide stable conjugates with controlled drug loading and release properties. On the other hand, electrostatic interaction can result in reversible conjugates that can be easily dissociated in response to changes in the surrounding environment.

Our Services

With the continuous development of organic chemistry, CD BioSciences is actively exploring technologies to engineer dendrimers. We are committed to helping our customers build dendrimer-ciprofloxacin conjugates based on organic chemistry platforms to reduce antibiotic resistance. All of our deliverables are subjected to rigorous quality testing and delivered on time.

Advantages of Our Services

Want to Learn More?

CD BioSciences provides the most comprehensive and effective solutions for engineering dendrimers. We are committed to helping our customers solve all the problems encountered in their dendrimer projects to meet the growing global demand for dendrimers. We have innovative dendrimer products and guarantee that all deliverables are subjected to rigorous quality testing. If you are interested in our services or have any other questions, please feel free to contact us and we look forward to working with you on your attractive projects.

Reference

1. Svenningsen SW, et al., Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate. Molecules. 2020, 25: 1389.