Cat#: CCR-0236
Azido-PEG4-phenyloxadiazole methylsulfone
Synonyms (s): 2-(4-(2-(2-(2-(2-Azidoethoxy)ethoxy)ethoxy)ethoxy)phenyl)-5-(methylsulfonyl)-1,3,4-oxadiazole
Empirical Formula (Hill Notation): C17H23N5O7S
Size: 10 mg
Product Introduction
| Molecular Weight | 441.46 |
| NACRES | NA.22 |
| MDL Number | MFCD26960813 |
| PubChem Substance ID | 329768888 |
| Assay | ≥95% |
| Form | Powder |
| Reaction Suitability | Reaction type: click chemistry |
| Smiles String | O=S(C(O1)=NN=C1C2=CC=C(OCCOCCOCCOCCN=[N+]=[N-])C=C2)(C)=O |
| InChI | 1S/C17H23N5O7S/c1-30(23,24)17-21-20-16(29-17)14-2-4-15(5-3-14)28-13-12-27-11-10-26-9-8-25-7-6-19-22-18/h2-5H,6-13H2,1H3 |
| InChI key | UPMDUJBOYVOHRH-UHFFFAOYSA-N |
| Storage Temp. | -20 °C |
Application
This is a heterobifunctional crosslinker that has a methylsulfonyl group to react with thiols on one end. The methylsulfonyl group is very specific for reacting with thiols in proteins at pH 5.8 to 8.0 and forms a bond that is more stable than that when using maleimide chemistry. The other end of the crosslinker contains an azide group that can react with an alkyne through Cu-mediated click chemistry or with strained alkynes in a Cu-free reaction.
Safety Information
| Storage Class Code | 11 - Combustible Solids |
| WGK | WGK 3 |
For research use only. Not for clinical use.
