Cat#: CLP-0072
Alkyne-PEG5-N-hydroxysuccinimidyl ester
Synonyms (s): Acetylene-PEG5-NHS ester, Alkyne-PEG5-NHS ester, Alkyne-PEG5-succinimidyl ester
Empirical Formula (Hill Notation): C18H27NO9
Size: 10 mg; 25 mg
Product Introduction
| Molecular Weight | 401.41 |
| NACRES | NA.22 |
| MDL Number | MFCD22574798 |
| PubChem Substance ID | 329767105 |
| Form | Powder |
| Reaction Suitability | Reaction type: Click chemistry; Reagent type: Cross-linking reagent |
| Smiles String | C#CCOCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O |
| InChI | 1S/C18H27NO9/c1-2-6-23-8-10-25-12-14-27-15-13-26-11-9-24-7-5-18(22)28-19-16(20)3-4-17(19)21/h1H,3-15H2 |
| InChI key | ACZDUKRWTPZVRP-UHFFFAOYSA-N |
| Storage Temp. | -20 °C |
Application
Heterobifunctional crosslinker enabling the connection of an azide containing compound or biomolecule to one with a primary amine. The succinimidyl ester group will react preferentially with primary amines to form a covalent adduct and the terminal alkyne will react with azides via copper-catalyzed 1,3-dipolar cycloaddition click chemistry. The hydrophilic PEG spacer adds to the water solubility of this reagent, allowing for easy modification amine containing biomolecules such as antibodies, proteins and peptides with the terminal alkyne. The PEG spacer also reduces aggregation of modified proteins stored in solution by adding hydrophilic character.
Safety Information
| Storage Class Code | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
For research use only. Not for clinical use.
