2-{2-[2-(2-Mercaptoethoxy)ethoxy]ethoxy}ethanol

Synonyms (s): MEEE, 1-Mercapto-11-hydroxy-3,6,9-trioxaundecane

Empirical Formula (Hill Notation): C₈H₁₈O₄S

Size: 500 mg

Product Introduction

Molecular Weight	210.29
MDL Number	MFCD22574773
PubChem Substance ID	329767336
Assay	0.98
Form	Crystals
Reaction Suitability	Reagent type: Cross-linking reagent
Smiles String	OCCOCCOCCOCCS
InChI	1S/C8H18O4S/c9-1-2-10-3-4-11-5-6-12-7-8-13/h9,13H,1-8H2
InChI key	GKKYNULPAQDGHI-UHFFFAOYSA-N

Application

2-{2-[2-(2-Mercaptoethoxy)ethoxy]ethoxy}ethanol may be used in the synthesis of 2-(2-(2-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio)ethoxy)ethoxy)ethanol, an nitrobenzoxadiazole (NBD) analog of the anticancer agent 6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio)hexan-1-ol (NBDHEX). This analog is a potent glutathione S-transferase (GST) and a potential therapeutic antimelanoma agent with enhanced water solubility and antitumor efficacy when compared to NBDHEX in a study.
Oligo-ehtylene glycol of peptides and small molecules (PEGylation)PEG-disulfide formationultra-thin protein-resistant monolayersDensely packed monolayer and a flexible-hydrophilic oligo ethylene glycol arm for avoiding non-specific adsorption

Safety Information

Signal Word	Danger
Hazard Classifications	Acute Tox. 3 Oral - Skin Corr. 1B
Storage Class Code	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3

For research use only. Not for clinical use.