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DDR1 Antibody
SPA-02862
| Size | Price |
| 100 µL | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | DDR1 |
| Gene Abbr. | DDR1 |
| Gene ID | 780 |
| Full Name | discoidin domain receptor tyrosine kinase 1 |
| Alias | CAK, CD167, DDR, EDDR1, HGK2 |
| Introduction | The discoidin domain receptors (DDRs) are receptor tyrosine kinases with a discoidin homology repeat in their extracellular domains, activated by binding to extracellular matrix collagens. So far, two mammalian DDRs have been identified: DDR1 and DDR2. They are widely expressed in human tissues and may have roles in smooth muscle cell-mediated collagen remodeling. Research studies have implicated aberrant expression and signaling of DDRs in human diseases related to increased matrix degradation and remodeling, such as cardiovascular disease, liver fibrosis, and tumor invasion. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 290420 |
| Isotype | IgG2A |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human DDR1. Asp19-Thr416. Accession # Q08345. |
| Usage | |
|---|---|
| Application | IP |
| Dilutions | Immunoprecipitation (25 µg/mL) |
| Reactivity | Human |
| Specificity | Detects human DDR1 in direct ELISAs and Western Blots. In direct ELISAs and Western Blots, this antibody does not cross-react with recombinant human DDR2. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.