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DAP12 Antibody
SPA-02780
| Size | Price |
| 0.05 mg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | DAP12 |
| Gene Abbr. | TYROBP |
| Gene ID | 7305 |
| Full Name | transmembrane immune signaling adaptor TYROBP |
| Alias | DAP12, KARAP, PLOSL, PLOSL1 |
| Introduction | This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Two alternative transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described, but their full-length nature has not been deterimined. [provided by RefSeq] |
| Product Details | |
|---|---|
| Host | Goat |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | Synthetic peptide C-KQRITETESPYQE from an internal region of human TYROBP / DAP12 (NP_003323.1; NP_937758.1). |
| Usage | |
|---|---|
| Application | ELISA, FC, IHC, ELISA |
| Dilutions | ELISA (1:100-1:2000); Immunohistochemistry (3-6 µg/mL) |
| Reactivity | Human, Canine, Equine, Primate, Rabbit, Sheep |
| Specificity | Human TYROBP / DAP12. This antibody is expected to recognize both reported isoforms (NP_003323.1; NP_937758.1). |
| Storage & Handling | |
|---|---|
| Storage Buffer | TBS (pH 7.3) and 0.5% BSA. |
| Preservative | 0.02% Sodium Azide |
| Storage Temp. | Store at -20 °C. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.