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CXCR4 Antibody
SPA-02573
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | CXCR4 |
| Gene Abbr. | CXCR4 |
| Gene ID | 7852 |
| Full Name | C-X-C motif chemokine receptor 4 |
| Alias | CD184, D2S201E, FB22, HM89, HSY3RR |
| Introduction | CXCR4 is a chemokine receptor that belongs to the G protein-coupled receptor family. It is activated by a small cytokine, CXCL12, also known as stromal cell derived factor 1 (SDF-1). The main function of CXCR4 is the mediation of the homing of progenitor cells in the bone marrow and their recruitment to sites of injury. More recently, CXCR4 has been studied, as a potential therapeutic target, in the context of autoimmune diseases as well as cancer, as the receptor is involved in the regulation of migration, proliferation, and survival of cancer cells.CXCR4 is phosphorylated at Ser339 by G protein-coupled receptor kinase 6 upon treatment of cells with CXCL12. Phosphorylation of CXCR4 at Ser339 has also been observed following epidermal growth factor and phorbol ester treatment. TCR-mediated transactivation of CXCR4 at Ser339 activates a PREX1-Rac1-signaling pathway that stabilizes interleukin-2, -4, and -10 messenger RNA transcripts. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 44717 |
| Isotype | IgG2B |
| Immunogen | 3T3 cells transfected with human CXCR4. |
| Usage | |
|---|---|
| Application | FC |
| Dilutions | Flow Cytometry (2.5 µg/10^6 cells); Neutralization (1-5 µg/mL) |
| MW(KDa) | 45-60 |
| Reactivity | Human |
| Specificity | Reacts specifically with human and non-human cells expressing human CXCR4 (fusin) as detected by flow cytometry. It will also react with cells expressing feline CXCR4 but not rat CXCR4. This antibody does not cross-react with other chemokine receptors. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.