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CXCL5 cDNA ORF Clone, Human, In cloning vector
SPD-04175
| Size | Price |
| 1 Unit | Online Inquiry |
| Description |
|---|
| Full length Clone DNA of Human chemokine (C-X-C motif) ligand 5. |
| Target Information | |
|---|---|
| Species | Human |
| Target Name | CXCL5 |
| Gene Abbr. | CXCL5 |
| Gene ID | 6374 |
| Full Name | C-X-C motif chemokine ligand 5 |
| Alias | ENA-78, SCYB5 |
| Introduction | CXCL5, also known as epithelial cell-derived neutrophil-activating peptide (ENA-78), is an 8 kDa proinflammatory member of the CXC subfamily of chemokines. Its Glu-Leu-Arg (ELR) motif confers angiogenic properties and distinguishes it from ELR-CXC chemokines which are angiostatic. Human CXCL5 shares 57% amino acid (aa) sequence identity with mouse and rat CXCL5. Among other human ELR+ chemokines, it shares 77% aa sequence identity with CXCL6/GCP-2 and35%‑51% with CXCL1/GRO alpha, CXCL2/GRO beta, CXCL3/GRO gamma, CXCL7/NAP-2, and CXCL8/IL-8. Inflammatory stimulation up-regulates CXCL5 production in multiple hematopoietic cell types, fibroblasts, endothelial cells, and vascular smooth muscle cells. In vivo, CXCL5 is elevated at sites of inflammation and pulmonary fibrosis where it promotes neutrophil infiltration and activation as well as angiogenesis. |
| Product Details | |
|---|---|
| Description | Full length Clone DNA of Human chemokine (C-X-C motif) ligand 5. |
| NCBI Ref Seq | NM_002994.3 |
| RefSeq ORF Size | 345 bp |
| Sequence Information | Identical with the Gene Bank Ref. ID sequence except for the point mutation 168 A/G not causing the amino acid variation. |
| Vector | pMD18-T Simple Vector |
| Quality Control | The plasmid is confirmed by full-length sequencing. |
| Storage | The lyophilized plasmid can be stored at ambient temperature for three months. |
| Usage | |
|---|---|
| Sequencing Primers | M13-47 and RV-M |
| Antibiotic in E.coli | Ampicillin |
| Shipping | Each tube contains lyophilized plasmid. |
| Storage | The lyophilized plasmid can be stored at ambient temperature for three months. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.