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CRTH-2/GPR44 Antibody
SPA-02420
| Size | Price |
| 0.025 mg | Online Inquiry |
| 0.1 mg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | CRTH-2/GPR44 |
| Gene Abbr. | PTGDR2 |
| Gene ID | 11251 |
| Full Name | prostaglandin D2 receptor 2 |
| Alias | CD294, CRTH2, DL1R, DP2, GPR44 |
| Introduction | The chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) is a recently identified receptor for the prostaglandin D2 (PGD2) in addition to the classic prostaglandin D receptor. CRTH2 is expressed on Th2 cells and eosinophils and mediates chemotaxis of these cells to PGD2 and is thus thought to be a key receptor mediating eosinophil and Th2 recruitment during allergic responses. However, CRTH2-null mice showed enhanced eosinophil recruitment into the lung consistent with observations that the CRTH2-null mice produced significantly higher amounts of interleukin-5 (IL-5) and IL-3. This suggests that CRTH2 plays a nonredundant role in restricting eosinophilia and allergic response in vivo. At least two different isoforms of CRTH2 are known to exist. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 54N3F8 |
| Isotype | IgG2B Kappa |
| Immunogen | Recombinant Protein containing multiple external domains of GPR44 (CRTH2) was used as immunogen for the antibody. NP_004769. |
| Usage | |
|---|---|
| Application | WB, IHC |
| Dilutions | Western Blot (1-5 µg/mL); Immunohistochemistry (1:20-1:1000) |
| Reactivity | Human |
| Specificity | GPR44, or G-protein coupled receptor 44, is also designated as CRTH2 and CD294. GPR44 is expressed specifically on CD4+ Th2 cells and type 2 cytotoxic effector cells. |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS. |
| Preservative | 0.05% Sodium Azide |
| Storage Temp. | Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.