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CRLR Antibody
SPA-02414
| Size | Price |
| 0.05 mL | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | CRLR |
| Gene Abbr. | CALCRL |
| Gene ID | 10203 |
| Full Name | calcitonin receptor like receptor |
| Alias | CGRPR, CRLR, LMPHM8 |
| Introduction | Calcitonin receptor-like receptor (CRLR) is an Adrenomedullin Receptor that requires two additional proteins to function: a chaperone protein RAMP (receptor activity modifying protein) and the component protein RCP. The function of CRLR depends on its interaction with RAMP. When coexpressed with RAMP1, CRLR acts as a receptor for calcitonin gene-related peptide (CGRP). In contrast, when CRLR is coexpressed with either RAMP2 or RAMP3, it acts as a receptor for adrenomedullin. Activation of the receptor leads to an increase in intracellular cyclic AMP. CRLR mediates the vasorelaxation of arteries, suggesting a potential role for the receptor in reaction to injury, particularly in the treatment of pulmonary hypertension. CRLR expression has been reported in brain, lung, blood vessel, liver, and intestinal tract. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human CALCRL. |
| Usage | |
|---|---|
| Application | IHC |
| Reactivity | Human, Rat, Porcine, Bovine, Canine, Equine, Goat, Hamster, Primate, Rabbit, Xenopus, Mouse, Fish, Guinea Pig, Primate-Orangutan, Zebrafish |
| Specificity | Human CALCRL. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except CALCR (56%). |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS. |
| Preservative | 0.1% Sodium Azide |
| Storage Temp. | Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.