Crk Antibody - CD BioSciences

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Crk Antibody

Crk Antibody

SPA-02374

Size Price
0.1 mL Online Inquiry
0.025 mL Online Inquiry
More Options Online Inquiry
Target Information
Target Name Crk
Gene Abbr. CRK
Gene ID 1398
Full Name CRK proto-oncogene, adaptor protein
Alias CRKII, p38
Introduction CREB is a bZIP transcription factor that activates target genes through cAMP response elements. CREB is able to mediate signals from numerous physiological stimuli, resulting in regulation of a broad array of cellular responses. While CREB is expressed in numerous tissues, it plays a large regulatory role in the nervous system. CREB is believed to play a key role in promoting neuronal survival, precursor proliferation, neurite outgrowth, and neuronal differentiation in certain neuronal populations. Additionally, CREB signaling is involved in learning and memory in several organisms. CREB is able to selectively activate numerous downstream genes through interactions with different dimerization partners. CREB is activated by phosphorylation at Ser133 by various signaling pathways including Erk, Ca2+, and stress signaling. Some of the kinases involved in phosphorylating CREB at Ser133 are p90RSK, MSK, CaMKIV, and MAPKAPK-2.
Product Details
Host Rabbit
Clonality Polyclonal
Clone No. N/A
Isotype IgG
Immunogen Recombinant protein encompassing a sequence within the center region of human CRK.
Usage
Application WB, IF
Dilutions Western Blot (1:500-1:3000); Immunofluorescence (1:100-1:1000)
MW(KDa) 42
Reactivity Human, Mouse
Storage & Handling
Storage Buffer PBS (pH 7), 40% Glycerol.
Preservative 0.01% Thimerosal
Storage Temp. Aliquot and store at -20 °C or -80 °C.
Handling Avoid freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.