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Corticotropin Releasing Factor Antibody
SPA-02304
| Size | Price |
| 0.1 mg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | Corticotropin Releasing Factor |
| Gene Abbr. | CRH |
| Gene ID | 1392 |
| Full Name | corticotropin releasing hormone |
| Alias | CRF, CRH1 |
| Introduction | Corticotropin-releasing hormone (CRH) is a 41-amino acid peptide derived from a 191-amino acid preprohormone. CRH is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in CRH has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin dificiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, CRH is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta CRH is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of CRH occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, CRH may act as a trigger for parturition. |
| Product Details | |
|---|---|
| Host | Sheep |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | An 18 amino acid synthetic CRF peptide (H-CEQLAQQAHSNRKLMEII-OH), conjugated to Keyhole Limpet Hemocyanin (KLH). |
| Usage | |
|---|---|
| Application | ELISA, IF, IHC |
| Dilutions | ELISA (1:100-1:10); Immunofluorescence (1:100); Immunohistochemistry (1:10-1:500) |
| Reactivity | Human, Mouse, Rat, Guinea Pig |
| Specificity | Specific for Corticotropin Releasing Factor. Confirmed by Immunohistochemical analysis of Paraffin Embedded Rat Brain (Hypothalamus). |
| Storage & Handling | |
|---|---|
| Storage Buffer | 0.05X PBS. |
| Preservative | No Preservative |
| Storage Temp. | Store at 4 °C for a short term. Aliquot and store at -80 °C for long-term storage. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.