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Chronophin/PDXP Antibody
SPA-02217
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | Chronophin/PDXP |
| Gene Abbr. | PDXP |
| Gene ID | 57026 |
| Full Name | pyridoxal phosphatase |
| Alias | CIN, PLP, dJ37E16.5 |
| Introduction | Cofilin is a conserved actin-severing protein required for processes that rely on actin dynamics, including cytokinesis and cell motility. Regulation of actin dynamics requires the controlled cycling between the phosphorylated and unphosphorylated forms of cofilin. The severing activity of cofilin is inhibited by LIMK or TESK phosphorylation at the conserved amino-terminal Ser3 of cofilin. Slingshot (SSH) phosphatase, for which there have been three mammalian isoforms identified, dephosphorylates cofilin in vivo. Chronophin (CIN, PDXP) is a haloacid dehalogenase phosphatase that also dephosphorylates cofilin. Alteration of CIN activity through overexpression of either the wildtype or phosphatase-inactive mutant CIN interferes with actin dynamics, cell morphology and cytokinesis. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone No. | C85E3 |
| Immunogen | Recombinant mouse MBP-chronophin. |
| Source/Purification | Antibody is produced by immunizing animals with recombinant mouse MBP-chronophin. |
| Usage | |
|---|---|
| Application | WB |
| Dilutions | Western Blot (1:1000) |
| MW(KDa) | 31 |
| Reactivity | Human, Mouse, Rat, Hamster, Monkey, Bovine |
| Sensitivity | Endogenous |
| Specificity | It detects endogenous levels of total chronophin/PDXP protein. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. |
| Preservative | Less than 0.02% Sodium Azide |
| Storage Temp. | Store at -20 °C. |
| Handling | Do not aliquot the antibody. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.