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CDK7 Antibody
SPA-02138
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | CDK7 |
| Gene Abbr. | CDK7 |
| Gene ID | 1022 |
| Full Name | cyclin dependent kinase 7 |
| Alias | CAK, CAK1, CDKN7, HCAK, MO15 |
| Introduction | CDK-activating kinase (CAK) is a complex of CDK7 and cyclin H. The complex is involved in cell cycle regulation by phosphorylating an activating residue in the T-loop domain of cdks. Regulation of CAK activity is mediated by T-loop phosphorylation and by association with MAT1, both of which enhance its kinase activity toward the CTD of RNA polymerase II (2,3) and other substrates such as p53. CAK is an essential component of the transcription complex TFIIH and may interact directly with TFIIH helicases. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | MO1 |
| Immunogen | Recombinant human CDK7. The epitope corresponds to a region surrounding Gln320 of human CDK7. |
| Source/Purification | Antibody is produced by immunizing animals with recombinant human CDK7. The epitope corresponds to a region surrounding Gln320 of human CDK7. |
| Usage | |
|---|---|
| Application | WB, IP, IHC |
| Dilutions | Western Blot (1:2000); Immunoprecipitation (1:200) |
| MW(KDa) | 40 |
| Reactivity | Human, Rat |
| Sensitivity | Endogenous |
| Specificity | It detects endogenous levels of total CDK7 protein. The antibody does not cross-react with other CDKs. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. |
| Preservative | Less than 0.02% Sodium Azide |
| Storage Temp. | Store at -20 °C. |
| Handling | Do not aliquot the antibody. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.