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CD40/TNFRSF5 Antibody
SPA-02041
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | CD40 |
| Gene Abbr. | CD40 |
| Gene ID | 958 |
| Full Name | CD40 molecule |
| Alias | Bp50, CDW40, TNFRSF5, p50 |
| Introduction | CD40 is a costimulatory molecule of the TNF receptor superfamily and is expressed on many cell types, such as B cells, monocytes/macrophages, dendritic cells, endothelial cells, fibroblasts or vascular smooth muscle cells. Interaction of CD40 and its ligand CD154 (CD40L) is required for the generation of antibody responses to T-dependent antigens as well as for the development of germinal centers and memory B cells. In monocytes/macrophages CD40 engagement induces production of pro-inflammatory cytokines and chemokines. CD40-CD154 interactions are also critical for development of CD4 T cell-dependent effector functions. CD40 links innate and adaptive immune responses to bacterial stimuli and serves as an important regulator affecting functions of other costimulatory molecules. |
| Product Details | |
|---|---|
| Host | Goat |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human CD40. Glu21-Arg193. Accession # P25942. |
| Usage | |
|---|---|
| Application | WB |
| Dilutions | Western Blot (2 µg/mL) |
| Reactivity | Human |
| Specificity | Detects human CD40 in direct ELISAs and Western Blots. In direct ELISAs, less than 5% cross-reactivity with recombinant mouse CD40 and recombinant rat CD40 is observed, and less 1% cross-reactivity with recombinant human (rh) TNF RI, rhsTNF RII, rhCD40 Ligand, rh4-1BB, rhCD27, rhCD30, rhDR3, rhDR6, rhFas, rhGITR, rhHVEM, rhNGF R, rhRANK and rhRELT is observed. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.